SODIUM BIS(TRIMETHYLSILYL)AMIDE

PRODUCT IDENTIFICATION
CAS NO. 42954-57-4; 1070-89-9; 133766-08-2

SODIUM BIS(TRIMETHYLSILYL)AMIDE

EINECS NO. 213-983-8
FORMULA [(CH3)3Si]2NNa
MOL WT. 183.37
H.S. CODE  
TOXICITY  
SYNONYMS Hexamethyldisilazane Sodium salt; NaHMDS;
Sodium bis(trimethylsilyl)amide; Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, Sodium salt; N-Sodiohexamethyldisilazane;
SMILES  

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE off-white crystalline powder
MELTING POINT 171 - 175 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER

Reacts

pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 3 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

  

FLASH POINT

 

STABILITY Stable under ordinary conditions. Moisture sensitive

GENERAL DESCRIPTION & APPLICATIONS
Hexamethyldisilazane (HMDS) is a strong hindered amine base but non-nucleophile (called harpoon base). The formula is (CH3)3Si-NH-Si(CH3)3 which consists of ammonia substituted with two trimethylsilyl groups. Silicon-consist alkali metal amides, such as Lithium hexamethyldisilazide (LiHMDS), Sodium hexamethyldisilazide (NaHMDS) are harpoon bases which are involved in kinetic deprotonation as the electron donor abstracts a proton. The advantages are that it is available as a solid and it is soluble in a wide range of nonpolar solvents. They are widely used in chemical reactions and transformation including Alkylation, base catalyzed reaction, condensation, dehalogenenation, deprotonations. elimination reaction, enolate formation, isomerization reaction, polymer application, selective metalation, super base application and transesterfication. Orher examples are Lithium diisopropylamide, Lithium tetramethylpiperidide, and alkali metal alcoholates.
Silazane

CAS RN.

1,1,3,3-Tetramethyl-1,3-diphenyldisilazane

3449-26-1

1,1,3,3-Tetramethyldisilazane

15933-59-2
1,3-Dibutyl-1,1,3,3-tetramethyldisilazane 82356-80-7

1,3-Diethyl-1,1,3,3-tetramethyldisilazane

17882-94-9

1,3-Dimethyl-1,1,3,3-tetraphenyldisilazane

7453-26-1
1,3-Dipropyl-1,1,3,3-tetramethyldisilazane 14579-90-9

2,2,4,4,6,6-Hexamethylcyclotrisilazane

1009-93-4
2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasilazane 5162-63-0

2,4,6-Trimethyl-2,4,6-trivinylcyclotrisilazane

5505-72-6
Hexaphenylcyclodisilazane 3284-07-9
Dimethylcyclosilazanes 68952-89-6
Methyl hydrogen methylvinylcyclosilazanes 503590-70-3
Octamethylcyclotetrasilazane 2587-47-5
Hexamethylcyclotrisilazane 2587-46-4
Hexaethylcyclotrisilazane 15458-87-4

Heptamethyldisilazane

920-68-3

Hexamethyldisilazane

999-97-3
Lithium bis(trimethylsilyl)amide 4039-32-1
Nonamethylstannasilazane 996-37-2
Octamethylcyclotetrasilazane 1020-84-4
Bis(chloromethyl)tetramethyldisilazane 14579-91-0
N-Sodiohexamethyldisilazane 1070-89-9
Nonamethyltrisilazane 1586-73-8
1,3-Divinyltetramethyldisilazane 7691-02-3
1,1,3,3-Tetramethyl-1,3-bis(3,3,3-trifluoropropyl)disilazane 39482-87-6
1,5-Dichloro-1,1-diphenyl-3,3,5,5-tetramethyltrisilazane 64426-36-4
1,5-Dichloro-1-ethenyl-1,3,3,5,5-pentamethyltrisilazane 64426-38-6
Silazanes 176948-80-4
SALES SPECIFICATION

APPEARANCE

 off-white crystalline powder
ASSAY

95% min (or 0.5M solution in toluene or tetrahydrofuran)

TRANSPORTATION
PACKING  
HAZARD CLASS 8 (Packing Group: II)
UN NO. 3263
OTHER INFORMATION
Hazard Symbols: C, Risk Phrases: 14-34, Safety Phrases: 26-28-36/37/39-45